Plain-English translation of NCT04998188 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a single injection of hydrolyzed collagen — a protein-based treatment — can help heal damaged cartilage in the knee and reduce pain and inflammation. About 204 people with knee osteoarthritis will participate. Half will receive the collagen injection, and half will receive a placebo (a harmless salt water injection), so researchers can fairly compare how well the treatment works.
Knee osteoarthritis causes cartilage to break down, leading to pain and stiffness that can persist even after physical therapy, medications, or other injections. Researchers want to see whether this medication might offer relief for people whose symptoms haven't improved with standard treatments.
You likely qualify if…
You likely don't qualify if…
You will come to the clinic for an initial evaluation, then receive one injection (either the collagen treatment or placebo) directly into your knee joint. After that, you'll have follow-up visits at 1, 3, and 6 months to check your progress — including questionnaires about your pain and a thermal imaging scan to measure inflammation in your knee. If you receive the placebo, you'll be offered the chance to cross over to the actual treatment after 6 months and be followed for an additional 6 months.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
Italy
Sponsor
Istituto Ortopedico Rizzoli
Enrollment target
~204 participants
Started
February 2022
Primary completion
December 2027
Age range
18 Years – 75 Years
Last updated on clinicaltrials.gov in February 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Roberta Licciardi, Msc
Istituto Ortopedico Rizzoli
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.