Plain-English translation of NCT05003310 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Rheumatoid Arthritis research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing a new device that stimulates the splenic nerve—a nerve connected to your spleen that may help control inflammation in rheumatoid arthritis. The trial will compare whether active nerve stimulation works better than a sham (placebo) treatment, and it will also test combining the stimulation with , an existing arthritis medication, to see if the two treatments work better together.
Many people with rheumatoid arthritis don't get enough relief from current biologic drugs and other standard treatments. This trial explores whether stimulating a specific nerve could be a new way to reduce the inflammation and pain of arthritis.
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You will first receive a minor surgical implant of the stimulation device. Then you will be randomly assigned to receive either active stimulation or sham stimulation for 12 weeks. Depending on your response, you may continue or switch treatments, and some participants will receive both the stimulation and the medication together for up to 24 weeks. After that, you will enter a long-term follow-up phase lasting 5 years, during which the research team will monitor your safety and how well the treatment is working.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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