Plain-English translation of NCT05004610 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing whether hypertonic sodium lactate, a specially formulated salt solution, can help protect the brain and heart in people who have survived cardiac arrest. When the heart stops and is then restarted, the organs can be damaged by the sudden return of blood flow — a problem called reperfusion injury. This medication may help reduce that damage and improve outcomes.
After cardiac arrest, even when the heart is successfully restarted, patients often suffer serious brain and heart damage that leads to death or long-term disability. Researchers have seen promising results with this medication in other types of injuries, and they want to find out whether it can help people who have just been resuscitated from cardiac arrest.
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After you are resuscitated and admitted to the hospital, you will be randomly assigned to receive either the new medication or standard IV fluids. If you receive the medication, you will get an IV infusion of hypertonic sodium lactate for 24 hours. Doctors will monitor you closely and take blood samples to measure whether the treatment reduces signs of organ damage and whether it is safe.
AI-generated summary from trial data · Aug 9, 2026 · Not medical advice
Belgium
Sponsor
Erasme University Hospital
Enrollment target
~125 participants
Started
February 2025
Primary completion
December 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2025.
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Central contact
Filippo Annoni, MD
Erasme University Hospital
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