Plain-English translation of NCT05011045 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study is tracking how whole brain radiation therapy affects patients' thinking, memory, and brain health after treatment for blood cancers like lymphoma and leukemia. Researchers will test your cognitive function (how your brain works), ask about your quality of life, and take brain imaging scans at several points over five years. The study will also look at whether a medication called Memantine might help protect brain function during and after radiation.
Whole brain radiation is an important treatment for certain blood cancers, but doctors want to understand what side effects it may have on thinking and memory. This information will help them better support patients and potentially find ways to protect brain health during and after this type of treatment.
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You would visit the clinic at specific times: before your radiation starts, and then again at 2 months, 6 months, 12 months, and once yearly for up to 5 years. At each visit, you'll complete thinking and memory tests (about 1–2 hours), fill out a short quality-of-life questionnaire (8–10 minutes), and have a brain MRI scan. All of these are standard tests your doctors would likely do anyway as part of your regular care—this study simply tracks the results to help researchers understand patterns.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
United States