Plain-English translation of NCT05011487 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a combination treatment for people with advanced lung cancer that has a specific genetic mutation. You would receive , a targeted medication that works against your cancer's mutation, combined with chemotherapy drugs before surgery to remove the tumor. The goal is to shrink the cancer as much as possible before your operation.
Standard treatment for this type of advanced lung cancer usually involves surgery followed by chemotherapy. Researchers want to see if giving this medication and chemotherapy *before* surgery might work better — potentially shrinking the tumor first, making surgery easier, and improving your chances of staying cancer-free longer.
You likely qualify if…
You likely don't qualify if…
You would take as a daily pill for about 2 months while also receiving two rounds of chemotherapy (given through an IV every 3 weeks). During this time, you'll have regular clinic visits for blood tests, scans, and check-ups to monitor how the treatment is working. After the medication and chemotherapy are finished, you would have surgery to remove the cancer, followed by standard post-surgery care.
AI-generated summary from trial data · Jul 3, 2026 · Not medical advice
China
Phase
Testing effectiveness
Sponsor
Sun Yat-sen University
Enrollment target
~30 participants
Started
August 2021
Primary completion
September 2023
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 75 Years
Last updated on clinicaltrials.gov in January 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Hong Yang, Ph.D.,M.D.
Sun Yat-sen University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.