Plain-English translation of NCT05013892 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a newer type of radiation therapy called normal tissue sparing whole brain radiation therapy (NTS-WBRT) designed to treat brain metastases—cancer that has spread to the brain from another part of the body. Unlike standard whole-brain radiation, this approach targets cancer more precisely while reducing radiation exposure to healthy brain tissue. You would also receive , a medication intended to help protect your brain during treatment.
Standard whole-brain radiation therapy can damage healthy brain tissue and affect memory and thinking skills. This trial exists to see whether this newer, more targeted form of radiation can fight cancer effectively while causing less harm to the parts of your brain that don't need treatment.
You likely qualify if…
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You would receive radiation therapy 5 days a week (Monday through Friday) for either 2 or 3 weeks, depending on your specific situation. At the same time, you would take daily for up to 24 weeks as a protective medication. You would have regular follow-up visits with your study doctor for evaluations and brain imaging, with the longest follow-up lasting up to 2 years after your radiation is complete.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
Massachusetts General Hospital
Enrollment target
~41 participants
Started
February 2022
Primary completion
December 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in April 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Helen A Shih, MD, MS, MPH
Massachusetts General Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.