Plain-English translation of NCT05020860 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether doctors can predict which patients will have complete cancer remission after chemotherapy by watching how well their tumors shrink in the first 1–2 months of treatment. Researchers are enrolling people with early-stage breast cancer (stages II and III) to receive standard chemotherapy drugs before surgery, and they'll study whether early signs of tumor shrinkage reliably signal complete response. The study will also explore whether blood tests and imaging scans can help predict which patients will benefit most from treatment.
Currently, doctors don't know until after a patient finishes all chemotherapy and has surgery whether the treatment worked completely. If researchers can predict success early, they could adjust treatment faster for patients who need it, and spare others from ineffective therapy.
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You will receive chemotherapy intravenously (through an IV) in two phases: first, one combination of drugs for 4 cycles (about 2 months), then a different combination for 4 cycles (another 2 months), for a total of about 4 months before surgery. During this time, your doctor will monitor your cancer with regular exams and imaging scans, especially after the first 1–2 cycles to see how well your tumor is responding. After you complete chemotherapy, you will have surgery to remove the remaining breast tissue, and doctors will examine the surgical specimen to see if cancer is completely gone.
AI-generated summary from trial data · Sep 2, 2026 · Not medical advice
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