Plain-English translation of NCT05030987 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing renal denervation—a minimally invasive procedure that calms overactive nerves connected to your kidneys—to see if it can help people with heart failure with preserved ejection fraction (HFpEF) feel better and live longer. HFpEF is a condition where your heart isn't pumping as forcefully as it should, even though the pumping chamber looks normal on tests. Researchers believe this treatment may reduce blood pressure, ease stress on your heart, and improve your ability to exercise.
Most heart failure treatments work well for one type of the condition, but HFpEF remains a serious challenge with no proven cure—patients still struggle with shortness of breath and fatigue. This trial exists because the new treatment may help by calming the nervous system, which is known to make heart failure worse.
If you qualify, you will be randomly assigned to either receive the renal denervation procedure or a sham (fake) procedure so researchers can fairly measure results. The procedure itself is minimally invasive—a catheter is threaded through a small incision to reach the nerves near your kidneys. You will have heart catheterization (a small tube inserted to measure pressures in your heart) as part of the screening and procedure. The trial involves visits to the University of Leipzig to monitor your blood pressure, heart function, symptoms, and quality of life over time.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
Germany