A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)

Active, not recruiting

Plain-English translation of NCT05031780 on ClinicalTrials.gov ↗ · Source last updated October 2026 · How we translate trials

Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.

Trial locations(91 sites)

United States

University of California San Diego, La Jolla, California

UCLA Health, Los Angeles, California

Children's Hospital Oakland, Oakland, California

University of Connecticut Health Center, Farmington, Connecticut

Children's National Hospital, Washington D.C., District of Columbia