Plain-English translation of NCT05032105 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Anxiety research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a procedure called MRI-guided focused ultrasound ablation (MRgFUSA) in people with epilepsy that hasn't responded to multiple anti-seizure medications and who also have moderate to severe anxiety. The procedure uses sound waves guided by MRI imaging to create a small, precise lesion in a specific part of the brain called the anterior nucleus of the thalamus. Researchers believe this treatment may reduce both seizures and anxiety symptoms.
Seizures that don't respond to medication are often accompanied by severe anxiety, which can be just as disabling as the seizures themselves. This trial is exploring whether this focused ultrasound treatment can safely address both problems at once—reducing seizure frequency while also helping with anxiety.
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If you're selected, you'll receive a one-time focused ultrasound procedure performed with MRI guidance. After the procedure, you'll return for follow-up visits at 1 day, 1 week, 1 month, 3 months, 6 months, and 12 months. During these visits, you'll undergo brain imaging scans (fMRI), neurological exams, cognitive testing, and anxiety assessments to track both safety and how well the treatment is working. You'll also maintain a seizure diary throughout the study.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
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