Recruiting

Two ways to remove large colon polyps: which works better?

Plain-English translation of NCT05041478 on ClinicalTrials.gov ↗ · Source last updated March 2025 · Translation generated August 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

Doctors sometimes need to remove large polyps from the colon during colonoscopy. This trial is testing two different removal techniques: one uses a cold snare (a wire loop that removes the polyp without heat), and the other combines the cold snare with a gentle heat treatment applied to the edges of where the polyp was removed. The study wants to see which approach works better at completely removing the polyp and preventing it from growing back.

The cold snare technique is very safe and causes fewer complications than older heated methods, but doctors aren't sure if it's equally effective at preventing polyps from coming back. This treatment aims to find out whether adding targeted heat to the removal edges can improve results while keeping the procedure as safe as possible.

Do you qualify?

You likely qualify if…

you are 18 years old or older
you have a large benign polyp (15–40 mm) in your colon or rectum that appears to be spreading sideways
the polyp shows specific benign features under magnified inspection during colonoscopy
you are willing to provide written consent to participate
you have no history of inflammatory bowel disease

You likely don't qualify if…

you are currently taking blood thinners or antiplatelet medications that have not been properly stopped before the procedure
you have a known bleeding disorder or blood clotting problem
you are pregnant
the polyp shows signs of having spread deeper into the colon wall or of cancer
the polyp is located near sensitive areas like the appendix or the junction between the small and large intestine

What participation looks like

During a colonoscopy, you will be randomly assigned to receive either the standard cold snare removal technique alone, or the cold snare removal followed by a gentle heat treatment applied to the edges of the removal site. Both techniques are performed during the same colonoscopy procedure under sedation. You may be invited back for follow-up colonoscopies to check whether the polyp has regrown, which helps the doctors compare how well each technique works over time.

AI-generated summary from trial data · Aug 14, 2026 · Not medical advice

Trial locations(1 site)

Australia

Westmead Endoscopy Unit, Westmead, New South Wales