Plain-English translation of NCT05046444 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Leukemia research guide →This research study is testing whether advanced genetic sequencing—a way of reading the complete genetic code of cancer cells—can help doctors diagnose blood cancers that remain unclear after standard diagnostic tests. Researchers have built a large reference library of over 5,500 blood cancer samples with known diagnoses, and they now want to test whether this genetic sequencing approach can solve diagnostic puzzles for patients whose cancer type cannot be clearly identified.
About 1 in 10 patients with suspected blood cancers cannot get a clear diagnosis even after undergoing all standard tests. This diagnostic uncertainty can delay treatment and make it harder to predict how the disease will behave. This study aims to show that advanced genetic sequencing can fill this gap and help doctors identify these hard-to-diagnose cancers.
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If you qualify, you will donate a blood or bone marrow sample that will be sent to the research laboratory for advanced genetic sequencing analysis. Your sample will be compared against the large reference library to help identify your specific diagnosis. The study will follow participants for up to nine months to see how the genetic sequencing results match with your clinical course and response to treatment. Most of your involvement will be the initial sample collection; results and findings will be shared with your medical team to guide your care.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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