Plain-English translation of NCT05048004 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Atrial Fibrillation research guide →This trial monitors patients undergoing pulmonary vein isolation—a catheter-based procedure to treat atrial fibrillation (irregular heartbeat)—to detect tiny blood clots that may form in the brain during treatment. Researchers will use transcranial doppler ultrasound, a safe non-invasive technique, to continuously track blood flow and identify which steps of the procedure create the highest risk of these clots. The study will also compare two different power settings used during the procedure to see which approach causes fewer clots.
While this procedure effectively treats irregular heartbeat, previous research shows it can sometimes cause tiny blood clots in the brain that may not cause obvious symptoms but could increase the risk of stroke or dementia over time. This study aims to pinpoint exactly which steps during the procedure are most risky and whether different techniques can reduce this complication.
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During your scheduled heart ablation procedure, researchers will perform continuous ultrasound monitoring of your brain using a small handheld probe held against your head. This safe, non-invasive monitoring allows them to detect any tiny clots as they form during the procedure. You will receive one of two ablation techniques (both standard treatments), and the ultrasound data will be recorded throughout to help identify which procedural steps create the most risk.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
Germany
Charite University, Berlin, Germany
Enrollment target
~20 participants
Started
December 2021
Primary completion
June 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Last updated on clinicaltrials.gov in August 2024.
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Central contact
Tim B Brämswig, MD
Charite University, Berlin, Germany
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