Plain-English translation of NCT05050929 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether a single, high-dose radiation treatment to tumors in the brain works as well as the standard five-treatment approach. The study compares two radiation schedules: one where you receive a single treatment, and another where you receive five treatments over one week. Both approaches use the same type of radiation therapy called volumetric modulated arc therapy, delivered through a standard radiation machine.
Cancer that has spread to the brain can cause serious symptoms and shorten survival. The standard treatment—five radiation sessions—requires multiple visits and can affect quality of life. Researchers want to know if giving the same dose in a single visit would work just as well, making treatment faster and less burdensome for patients with limited time.
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If you join this trial, you will be randomly assigned to receive either one radiation treatment or five radiation treatments over one week. Both treatments will be delivered on an outpatient basis using a standard radiation machine—no surgery is involved. You will need regular follow-up imaging scans after treatment and will be asked to complete quality-of-life questionnaires to help researchers understand how the treatment affects you.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
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