Plain-English translation of NCT05051397 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing whether changing carbon dioxide levels in your breathing during general anesthesia can help protect brain tissue during emergency stroke treatment. You would be having mechanical thrombectomy — a procedure to remove a blood clot from a major artery in your brain — and researchers want to see if managing your breathing in a specific way during surgery might improve blood flow to the damaged area and improve your outcome.
When someone has a major stroke caused by a blood clot, time is critical and brain tissue is at risk. Researchers believe that carefully controlling carbon dioxide levels during the procedure might help improve blood flow to the brain tissue that is still salvageable, potentially leading to better recovery.
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You would be randomly assigned to one of two groups that differ only in the exact carbon dioxide level targeted during your anesthesia — either a slightly higher or normal level. During your emergency stroke procedure, doctors will monitor your breathing and blood gases carefully to maintain your assigned carbon dioxide level. Blood samples will be taken at the beginning and end of the procedure to measure your actual carbon dioxide levels, and imaging will be used to assess blood flow in your brain during the procedure.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
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