Plain-English translation of NCT05055648 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This international trial is testing whether proton therapy—a newer, more precise form of radiation—works as well as or better than standard photon radiation for treating esophageal cancer. All participants receive chemotherapy (carboplatin and paclitaxel) combined with radiation, followed by surgery to remove the tumor. The main goal is to see if proton therapy reduces side effects while being equally effective at treating the cancer.
Standard radiation therapy for esophageal cancer can damage healthy tissue around the tumor, sometimes causing serious side effects. Proton therapy is designed to deliver radiation more precisely to the tumor while sparing nearby organs, potentially improving quality of life after treatment.
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You will be randomly assigned to receive either standard photon radiation or proton radiation, combined with weekly chemotherapy infusions over several weeks. The radiation treatment is given five days a week for either 4.5 or 5.5 weeks, depending on your treatment center's protocol. After completing chemotherapy and radiation, you will have surgery to remove the affected portion of your esophagus or stomach. You will then be followed closely with regular clinic visits and imaging tests to monitor your recovery and watch for side effects.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
Belgium
Denmark
France