Screening for pancreatic cancer in high-risk gene carriers

This pilot study is looking at whether regular screening with imaging tests—specifically MRI and ultrasound—can catch early warning signs of pancreatic cancer in people who carry specific genetic mutations (BRCA1, BRCA2, ATM, or PALB2) that put them at higher risk. The study will track participants over 10 years to see how often these imaging tests find abnormalities and whether they help catch cancer earlier.

Pancreatic cancer is often found very late, when it's harder to treat. People with certain genetic mutations have a much higher risk of developing this cancer, but there's no standard screening approach for them. This trial is testing whether regular imaging can find precancerous changes or early cancers in these high-risk patients before symptoms appear.