Plain-English translation of NCT05065372 on ClinicalTrials.gov ↗ · Source last updated ·
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing whether metformin, a medication that improves how your body uses insulin, can help protect your kidneys and heart when used together with an automated insulin delivery system. Young people with type 1 diabetes often face serious kidney and heart problems as they get older. Researchers want to see if the medication might prevent or slow down these complications.
People with type 1 diabetes have a much higher risk of kidney disease and heart problems, especially as time goes on. While automated insulin pumps have improved blood sugar control, doctors aren't sure whether adding this medication might provide extra protection for the heart and kidneys—something that hasn't been studied before.
You likely qualify if…
You likely don't qualify if…
You would take either the study medication or a placebo pill (a pill with no active ingredient) once daily for 4 months. During the study, you'll have several clinic visits where researchers will do special tests to measure how your kidneys and heart are functioning, including blood tests, imaging, and a test where they give you insulin through an IV to see how your body responds. The entire study lasts about 4 months, and some tests take a few hours to complete.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States