Testing HIV and TB medication doses in young children

This trial is testing dolutegravir, an HIV medication, to understand how it works in the bodies of very young children who have both HIV and tuberculosis at the same time. Researchers want to see if the standard dose of the medication is safe and effective when children are also taking tuberculosis medicines, and whether increasing the tuberculosis medicine dose affects how the HIV medication works. The study will follow children for 48 weeks and collect blood samples at key time points to measure medication levels.

When children have both HIV and tuberculosis, they need to take medicines for both infections at the same time, but these medicines can interact with each other in ways that aren't fully understood in very young children. This trial aims to fill that knowledge gap so doctors can prescribe the right doses to keep children safe and healthy.