Plain-English translation of NCT05078957 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research study is looking at the bacteria living in your gut (called your microbiota) in people with HIV who have their virus well-controlled by antiretroviral treatment. Researchers want to understand how these bacteria change over 5 years and whether those changes are connected to aging faster and becoming frail — something that happens about 10 years earlier in people with HIV compared to people without HIV.
People with HIV tend to show signs of aging and frailty much earlier than others, even when their virus is well-controlled by medication. Scientists think an imbalance in gut bacteria may be partly responsible, so this study aims to understand this connection better and eventually find ways to help.
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You would visit the clinic for appointments over 5 years, during which you would provide stool samples so researchers can analyze your gut bacteria. Depending on how frail or healthy you are, you'll be placed into one of three groups — frail, pre-frail, or not frail — which helps the researchers compare how your microbiota changes over time. The study involves no medications to take; it's purely observational, meaning researchers are watching and learning rather than testing a new treatment.
AI-generated summary from trial data · Jun 23, 2026 · Not medical advice
France