Gel to prevent skin damage from breast cancer radiation therapy

Plain-English translation of NCT05079763 on ClinicalTrials.gov ↗ · Source last updated January 2026 · Translation generated July 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing a new gel called bacterial cellulose-monolaurin hydrogel to see if it can prevent or reduce severe skin damage that occurs during radiation therapy for breast cancer. Radiation therapy can cause painful skin burns and peeling, which many patients experience. This study will compare the new medication to a placebo cream to see if it works better at protecting the skin.

Almost all breast cancer patients getting radiation therapy develop skin damage that can be painful, affect their quality of life, and sometimes make them want to skip or stop their treatment. Right now, doctors don't have a clear best way to prevent this problem, so researchers want to test whether this treatment can help.

Do you qualify?

You likely qualify if…

you are a woman at least 18 years old
you have been diagnosed with breast cancer
you have already completed surgery (mastectomy) and chemotherapy
you are scheduled to receive radiation therapy after your surgery and chemotherapy
you are healthy enough to participate (measured by your doctor's assessment)

You likely don't qualify if…

you are pregnant or breastfeeding
you have ever been treated for any other type of cancer
you have had radiation therapy to your chest area before
you have an active skin infection or other skin condition in the area that will receive radiation
you are allergic to any ingredient in the gel or placebo cream

What participation looks like

If you join this trial, you'll be randomly assigned to receive either the new gel or a placebo cream. You'll apply your assigned treatment to the radiation area twice a day, starting from your first radiation session and continuing for up to two weeks after your last radiation treatment, or until your skin shows signs of severe damage. The researchers will check how your skin is doing during and after your radiation therapy to see if the gel helped prevent damage.

AI-generated summary from trial data · Jul 3, 2026 · Not medical advice

Trial locations(1 site)

Philippines

Philippine General Hospital, Manila