Plain-English translation of NCT05080946 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Ovarian Cancer research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing whether aspirin, a common over-the-counter pain reliever, can help your body's immune system fight ovarian, fallopian tube, or peritoneal cancer more effectively. You would take aspirin daily while receiving standard chemotherapy treatment before surgery. Researchers want to see if this medication can reduce the tumor's ability to suppress your immune response.
Current chemotherapy treatments can sometimes suppress the immune system's ability to fight cancer cells. This study explores whether this treatment might reverse that effect and help your own immune system become a more powerful partner in fighting your cancer.
If you enroll, you will be randomly assigned to either take aspirin (325 mg daily) or a placebo (an inactive pill that looks identical). You will take your assigned pill every day while receiving your planned chemotherapy over 3 to 5 months. You will attend regular visits for blood work and exams. The main part of the study ends when you have your interval debulking surgery, where researchers will collect tissue samples to measure changes in your immune response.
AI-generated summary from trial data · Sep 19, 2026 · Not medical advice
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