Plain-English translation of NCT05098847 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a combination treatment for cancer that has spread to the liver and stopped responding to earlier therapies. The treatment combines three approaches: (a procedure that freezes tumors), (an immunotherapy medication), and (a targeted therapy drug). The idea is that freezing the tumor may help wake up your immune system to fight the cancer, while the two medications work together to boost that immune response.
When cancer spreads to the liver and stops responding to standard treatments, options are limited. Recent research suggests that freezing tumors may activate the immune system in a way that makes immunotherapy drugs work better, so researchers want to test whether combining all three approaches could help more patients.
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You would receive a procedure to freeze the tumors in your liver, then take two medications ( and ) by mouth or infusion on a regular schedule. You'll have multiple visits to the hospital or clinic for treatment, imaging scans to monitor how your tumors respond, and blood tests to check your health and safety. The trial expects to enroll about 25 people and will track your progress over several months.
AI-generated summary from trial data · Jun 30, 2026 · Not medical advice
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