Combined heart rhythm and clot prevention procedure for atrial fibrillation

This trial is studying a combined procedure for people with atrial fibrillation—a condition where the heart beats irregularly. The procedure combines two treatments done at the same time: catheter ablation (which uses heat or cold to fix the irregular heartbeat) and left atrial appendage closure (a device placed in the heart to prevent clots and stroke). Researchers want to measure how the pressures in your heart chambers change during and after the procedure, and whether these changes affect your long-term health outcomes.

Many people with atrial fibrillation are at high risk for stroke but cannot take blood thinning medications due to side effects or other medical reasons. This trial wants to understand whether doing both treatments together—fixing the heartbeat and closing off the area where clots can form—improves outcomes, and how measuring heart pressure during the procedure might help predict who will do well.