Focused radiation therapy for remaining lung cancer nodules after surgery

Plain-English translation of NCT05113017 on ClinicalTrials.gov ↗ · Source last updated November 2025 · Translation generated June 2026 · How we translate trials

What is this trial?

This trial is testing stereotactic body radiation therapy (SBRT)—a type of precise, high-dose radiation treatment—for patients who have multiple lung nodules (small spots) and have already had lung cancer surgery. SBRT is designed to target remaining or new lung nodules without affecting surrounding healthy tissue. The study wants to see how well and how safely this treatment works for people who either cannot have another surgery or prefer not to.

Some patients with lung cancer develop multiple nodules over time, but having surgery to remove each one is difficult or dangerous. This treatment offers an alternative option that may help patients avoid repeated surgeries while still treating their cancer.

Do you qualify?

You likely qualify if…

you are between 18 and 75 years old
you have been diagnosed with lung cancer in at least one lung nodule, confirmed by biopsy
you have at least two lung nodules visible on a chest CT scan
your remaining lung nodules cannot be surgically removed, or you have chosen not to have another surgery
you are in good enough overall health to tolerate this treatment (ECOG score 0–2)
you can swallow tablets and are able to give informed consent

You likely don't qualify if…

you have cancer that has spread to other parts of your body
you have previously received radiation therapy to your chest
you have lymph node involvement or distant metastases (cancer spread)
your lung nodules are located near the main airways in your lungs
you have severe heart, liver, kidney, or blood disorders

What participation looks like

If you join this trial, you will receive stereotactic body radiation therapy (SBRT) as an outpatient treatment for your lung nodules. The study will monitor how well the treatment works and watch for any side effects through imaging scans and clinical visits. Your doctors will track your progress and lung health over time to understand whether this focused radiation therapy is both effective and safe for people with multiple lung nodules.

AI-generated summary from trial data · Jun 9, 2026 · Not medical advice

Trial locations(5 sites)

China

Oncology Department，Second Xiangya Hospital of Central South University, Changsha, Hunan

Hunan Cancer Hospital, Changsha

The Third Xiangya Hospital, Central South University, Changsha

Xiangya Hospital, Central South University, Changsha

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan