Plain-English translation of NCT05124236 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether giving radiation therapy before brain surgery works better than giving it after surgery, for patients with cancer that has spread to the brain. Both approaches use focused, high-dose radiation to treat the tumor and reduce the chance it comes back. The study wants to find out which timing helps patients live longer and keeps their thinking and memory sharper.
Currently, doctors usually give radiation after surgery, but early research suggests that giving radiation before surgery might prevent the cancer from spreading in the brain better and with fewer side effects. This trial will test whether changing when the radiation is given makes a real difference for patients.
You likely qualify if…
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You will be randomly assigned to receive either radiation before your scheduled brain surgery or radiation in five treatments after surgery. If assigned to receive radiation before surgery, you'll have one radiation appointment before your operation. If assigned to the standard approach, you'll have radiation appointments spread over one week following your surgery. Either way, you'll have follow-up visits and imaging scans to check how well the treatment worked and monitor for any side effects.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
Austria
Germany
Switzerland