Plain-English translation of NCT05124912 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The REMASTer trial is testing a procedure called Laser Interstitial Thermal Therapy (LITT) for patients with brain metastases (cancers that spread to the brain) that have come back after stereotactic radiosurgery. This minimally invasive laser treatment uses heat to destroy problematic brain lesions. The trial is comparing two approaches: using LITT alone with monitoring versus LITT followed by additional radiation therapy, to see which works best.
When brain tumors return after radiation treatment, doctors need effective options to help patients. Some returning lesions may be new tumor growth, while others may be scar tissue from radiation damage. This trial aims to determine the best way to use laser heat treatment — and whether adding follow-up radiation helps — so doctors can offer patients the most effective care.
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If you join this trial, you will undergo a minimally invasive procedure in which surgeons use a laser to heat and destroy the problematic brain lesion. A small tissue sample will be taken during surgery to confirm whether the lesion is new tumor growth or radiation-related scar tissue. Depending on which group you're randomly assigned to, you may receive the laser treatment alone and then be monitored with follow-up imaging, or you may receive the laser treatment followed by additional radiation therapy. You'll have regular follow-up visits and imaging scans to track how you're doing.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
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