Plain-English translation of NCT05126290 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
The CAFÉ Study is trying to understand how a specific genetic change called a CTNNA1 loss-of-function variant affects cancer risk in families. Researchers want to learn which types of cancer are more common in people who carry this genetic change, and whether different versions of the change cause different levels of risk. This information will help doctors better advise people who carry this genetic change about their cancer screening and prevention options.
Right now, doctors don't fully understand how this genetic change affects cancer risk or which family members might need closer monitoring. By collecting detailed family and medical histories from people who carry this change, researchers can create clearer guidelines to help protect the health of affected families.
You likely qualify if…
You likely don't qualify if…
This is a registry and information-gathering study, not a treatment trial. You would share your personal medical history and your family's cancer history with the research team. The study team may also ask you to provide or authorize release of medical records. There is no medication to take or invasive procedures involved — it is primarily about documenting health information to help researchers understand patterns of cancer risk in families with this genetic change.
AI-generated summary from trial data · Aug 5, 2026 · Not medical advice
United States
Sponsor
Abramson Cancer Center at Penn Medicine
Enrollment target
~100 participants
Started
March 2021
Primary completion
January 2028
Age range
18 Years and older
Last updated on clinicaltrials.gov in February 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Bryson W Katona, MD, PhD
University of Pennsylvania
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.