Plain-English translation of NCT05129605 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
The PROGRESS study is looking for men who may be at higher risk of prostate cancer because of inherited genetic mutations or a strong family history of the disease. Researchers will use prostate exams, PSA blood tests, and MRI imaging to screen these men over time and learn more about how specific genetic changes affect cancer development and which men need earlier or more frequent screening.
Prostate cancer runs in some families because of inherited genetic mutations, but doctors don't fully understand which mutations matter most or how to best catch cancer early in men who carry them. This study aims to fill that gap so that high-risk men can get the right screening at the right time.
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If you enroll, you will have regular prostate screening visits that include a physical prostate exam, a PSA blood test, and a prostate MRI scan. You will also be asked to provide blood or tissue samples for genetic testing and research. The study follows you over time to track whether you develop prostate cancer and to learn how your genetic risk factors influence your health outcomes.
AI-generated summary from trial data · Jun 27, 2026 · Not medical advice
United States