Plain-English translation of NCT05133102 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Researchers want to see if they can diagnose Barrett's esophagus — a condition where cells in the food pipe change in ways that can lead to cancer — by testing saliva instead of only using an endoscopy (a camera procedure down the throat). This study will collect saliva samples multiple times from people with and without Barrett's esophagus to see if the bacteria in saliva can reliably identify who has the condition.
Currently, the only way to diagnose Barrett's esophagus is with an uncomfortable endoscopy procedure. If saliva testing could detect this condition, it would give doctors a simpler, non-invasive tool to screen for and monitor the disease before it becomes cancer.
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You will be asked to provide saliva samples at one or more visits, likely around the time of an upper endoscopy appointment or within the timeframe of a recent endoscopy. The study will collect your saliva multiple times to see if the bacterial patterns are consistent and can reliably detect Barrett's esophagus. The saliva collection itself is simple and non-invasive — just spitting into a container — and takes only a few minutes.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States
Sponsor
Columbia University
Collaborators
University of Michigan, National Cancer Institute (NCI)
Enrollment target
~275 participants
Started
March 2021
Primary completion
August 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in May 2026.
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Central contact
Julian Abrams, MD
Columbia University
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