Plain-English translation of NCT05134012 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Coronary Artery Disease research guide →Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether [15-O]-H2O, a radioactive water-based tracer, can help doctors better identify blockages in the arteries that supply blood to your heart. You would receive two doses of this tracer during a single PET imaging session—one while resting and one while your heart is stressed with medication. The goal is to confirm that this new imaging method can accurately detect coronary artery disease in people like you who are suspected of having heart artery problems.
Doctors need better ways to diagnose heart artery blockages early and accurately. This medication and imaging approach may help identify disease more reliably than some current tests, which could lead to better treatment decisions and outcomes for patients with suspected heart problems.
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You will come to the study site for a single imaging session lasting a few hours. During this visit, you will receive two small injections of the radioactive tracer—first while resting, and then again while your heart is stimulated with medication (adenosine) to increase blood flow. A PET scanner will image your heart during both conditions to see how blood flows through your arteries. After the scan is complete, the research team will call you 24 hours later to check that you are doing well.
AI-generated summary from trial data · Jun 25, 2026 · Not medical advice
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