Optimizing breathing support setup for motor neuron disease patients

This trial is testing whether a personalized approach to setting up non-invasive ventilation (NIV)—a breathing assistance device that uses gentle air pressure through a mask—works better than the standard setup method for people with motor neuron disease. Half of participants will have their NIV settings adjusted based on detailed information from a sleep study, while the other half will receive the standard setup. The goal is to help more people use this life-extending treatment comfortably for long enough each day to get real benefits.

Many people with motor neuron disease struggle to tolerate or use breathing assistance regularly, even though it can extend their life and improve how they feel. A smaller study showed that customizing the device settings based on a sleep study helped people use it better, so this larger trial is testing whether that improvement holds true across multiple hospitals and over a longer period of time.