Plain-English translation of NCT05142735 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether N-acetylcysteine, a supplement available over the counter, can help reduce early psychosis symptoms in people at clinical high risk for schizophrenia. The study will also measure how the medication affects brain activity patterns related to how the brain processes sounds and word meanings. Researchers believe this treatment might prevent the onset of more serious psychotic illness.
People sometimes experience early warning signs of psychosis before developing schizophrenia. This medication has shown promise in other research, and this trial will test whether it can help reduce these early symptoms and improve brain function—potentially preventing the condition from progressing.
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You will take either the supplement or a matching placebo tablet by mouth every morning for 8 weeks. During the study, you will have visits at the start, week 4, and week 8 to answer questions about your symptoms. At the beginning and end of the study, you will also have a brief test where you listen to sounds and respond to words while researchers measure your brain activity using sensors on your head. The entire study lasts 8 weeks.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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