Plain-English translation of NCT05144503 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Atrial Fibrillation research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing the SpherePVI™ Catheter, a new medical device used during a catheter ablation procedure to treat paroxysmal atrial fibrillation — a type of irregular heartbeat. The SpherePVI™ Catheter works by carefully applying heat energy inside the heart to correct the faulty electrical signals that cause the irregular rhythm. Researchers want to make sure this device is safe and works well for people whose irregular heartbeat symptoms haven't improved with medication alone.
Atrial fibrillation can cause serious symptoms and increase the risk of stroke, but not everyone benefits from or can tolerate heart rhythm medications. This trial exists to determine whether the SpherePVI™ Catheter offers a safe and effective option for treating this condition in people who need an alternative to drugs.
You likely qualify if…
You likely don't qualify if…
If you qualify, you would undergo a catheter ablation procedure using the SpherePVI™ Catheter device, where doctors guide a thin tube through a vein to your heart and use heat energy to correct the irregular rhythm. Before and after the procedure, you would have imaging tests, blood work, and heart rhythm monitoring (such as EKGs) to make sure the treatment is working safely. You would need to attend follow-up appointments and comply with all testing requirements as part of the study.
AI-generated summary from trial data · Sep 20, 2026 · Not medical advice
Lithuania
Sponsor
Medtronic Cardiac Ablation Solutions
Enrollment target
~100 participants
Started
July 2021
Primary completion
September 2029
Age range
18 Years – 75 Years
Last updated on clinicaltrials.gov in September 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Sandra Jacobs
Medtronic Cardiac Ablation Solutions
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.