Plain-English translation of NCT05149196 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
When surgeons remove a kidney due to cancer, the remaining kidney is at risk of injury during and after surgery. This trial is testing a strategy called goal-directed hemodynamic management—which means carefully controlling your blood pressure, fluids, and heart function during surgery and for 48 hours afterward—to see if it can prevent or reduce kidney damage. About half of patients undergoing this surgery develop acute kidney injury, which can lead to long-term kidney problems, so the trial aims to find ways to protect kidney health.
Kidney injury is very common after kidney removal surgery and can lead to chronic kidney disease and serious kidney failure down the road. Early studies suggest that keeping blood pressure and blood flow at optimal levels during and right after surgery might help prevent this damage, but doctors need to know if this approach really works.
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You will undergo your scheduled kidney removal surgery. If you are randomly assigned to the treatment group, your anesthesia team will use extra fluids, heart-boosting medications, and careful monitoring to maintain optimal blood pressure during surgery and for the first 48 hours afterward. The comparison group receives standard surgical care. Your kidney function will be monitored closely in the weeks and months following surgery to see if the targeted blood pressure management approach helps protect your remaining kidney.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
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