Plain-English translation of NCT05153967 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Sickle Cell Disease research guide →Sickle cell disease now has newer treatments that can potentially cure the disease, including stem cell transplants and gene therapy. This study follows patients who receive these curative treatments — as well as those receiving standard care — to carefully measure both the benefits and any long-term side effects that might develop over time.
While these new curative treatments show promise, doctors don't yet have enough long-term information about what happens to patients months or years after treatment. Some concerning side effects have already started to appear, so researchers need to understand the true risks versus benefits of these treatments to help patients make the best choices for their own health.
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Depending on which group you join, you will either be followed after receiving a curative treatment like a stem cell transplant, or you will continue with your standard sickle cell care. The study involves sharing your medical information and test results — such as lung function tests, heart imaging, and kidney function measurements — collected over time at your regular doctor visits. Researchers will track how your heart, lungs, and kidneys function over months and years to compare outcomes between those who received curative treatment and those receiving standard care.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
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