Plain-English translation of NCT05165706 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Diabetes Mellitus, Type 2 research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study is testing whether different types of diets—Mediterranean low-carb, standard low-carb, or low-fat with healthy carbs—affect how your body processes insulin and manages weight. Researchers will track changes in your blood and fat tissue to understand why some overweight people develop insulin resistance (difficulty using insulin to control blood sugar) while others don't.
Obesity affects millions of people worldwide, but scientists don't fully understand why some overweight individuals develop insulin resistance while others stay healthy. This study aims to identify the biological changes that happen during weight gain and loss, which could help doctors better prevent and treat weight-related metabolic problems.
You likely qualify if…
You likely don't qualify if…
You'll be randomly assigned to one of three diet groups and receive personalized instruction from a registered dietitian. Over 13 weeks, you'll follow your assigned eating plan while researchers measure your body's response through blood tests and fat tissue samples. The study includes a controlled weight-gain phase (about 5 weeks) followed by a weight-loss phase (8 weeks) to see how your body adapts to these changes.
AI-generated summary from trial data · Jun 6, 2026 · Not medical advice
United States