Plain-English translation of NCT05166343 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
When a child's heart stops beating outside a hospital, paramedics and first responders need to act fast. This trial is testing epinephrine—a medication that helps restart the heart—given as a quick intramuscular injection (like an EpiPen) as the very first dose, rather than waiting to place an intravenous line. The goal is to see if this faster method can help more children survive and recover better.
Every second counts when a child's heart stops. Right now, paramedics spend time trying to place an IV line before giving lifesaving medication, which can delay treatment. This trial is asking: could this medication work just as well—or even better—if given more quickly through a simple intramuscular injection?
You likely qualify if…
You likely don't qualify if…
If your child is in cardiac arrest and meets the study criteria, paramedics will either give the first dose of heart medication using the standard intravenous method (the control group) or through an intramuscular injection (the new method being tested). All other emergency care remains the same. The trial tracks how quickly the medication is given and whether the child's heart restarts and how well they recover afterward.
AI-generated summary from trial data · Aug 6, 2026 · Not medical advice
Canada
Phase
Large-scale testing
Sponsor
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Enrollment target
~284 participants
Started
January 2024
Primary completion
January 2028
Age range
1 Day – 17 Years
Last updated on clinicaltrials.gov in March 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Maysaa Assaf
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.