Plain-English translation of NCT05172921 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Thyroid Cancer research guide →Thyroid cancer rates have nearly tripled since the 1970s, and researchers want to understand why. This study collects tiny blood samples from people with thyroid nodules to measure what chemicals and pollutants are in their bodies, and whether these exposures might be connected to thyroid cancer risk. By studying these exposures, researchers hope to better understand why some people develop thyroid cancer.
We know radiation can increase thyroid cancer risk, but that only explains about half of the increase we're seeing. Researchers suspect that everyday environmental chemicals — especially those that affect hormones — may play a role, but they need better evidence to understand the connection.
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You will provide small blood samples using a simple home-based device called a dried blood microsampler — it's much less invasive than traditional blood draws and doesn't require a needle stick at a lab. Your samples will be analyzed to measure environmental exposures and metabolic changes. The study is comparing people with high environmental exposures to those with low exposures to see if these factors are linked to thyroid cancer outcomes.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States
Enrollment target
~500 participants
Started
February 2022
Primary completion
September 2030
Age range
18 Years and older
Last updated on clinicaltrials.gov in October 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Maaike van Gerwen, MD, PhD
MSH
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.