Moving more and resistance training to help kidney disease and weight

This research study is testing whether combining exercise guidance, strength training, and semaglutide—a medication approved for weight loss and diabetes—can help people with moderate kidney disease reduce how much time they sit and increase physical activity. The study builds on earlier research showing that sitting less helps protect kidney function, but people struggled to keep up the habit long-term. Researchers want to see if adding strength training and this medication can make the activity program easier to stick with.

People with kidney disease who sit for long periods face faster decline in kidney function and higher risks of diabetes, heart disease, and death. An earlier study showed that reducing sitting time helped, but the benefit didn't last—so researchers are now testing whether adding strength training and the medication can help people maintain these healthier habits over time.