Plain-English translation of NCT05180591 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Diabetes Mellitus, Type 1 research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether BCG (), a vaccine that has been used safely for many years, might help treat type 1 diabetes in children. Early studies in adults showed that this medication helped calm the immune system's attack on the pancreas and improved blood sugar control for years. This study will test whether children experience even greater benefits.
Type 1 diabetes happens when the immune system mistakenly attacks cells in the pancreas that make insulin. Current treatments help manage blood sugar but don't stop this immune attack. This trial is exploring whether this medication can actually reset the immune system and restore some of the body's ability to make its own insulin.
If you join, you will receive either two injections of the study medication or two placebo (inactive) injections, given one month apart. You will then be followed by the research team for 5 years with regular check-ups to monitor your blood sugar levels, insulin use, and overall health. Throughout the study, you will need to wear a continuous glucose monitor and keep careful track of your blood sugar.
AI-generated summary from trial data · Jul 2, 2026 · Not medical advice
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