Plain-English translation of NCT05180591 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Diabetes Mellitus, Type 1 research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether BCG (a vaccine that's been used safely for over 100 years) can help treat type 1 diabetes in children aged 8 to 17. Early studies in adults showed that repeated BCG vaccinations may slow down the immune cells that attack the pancreas, help the pancreas produce some insulin again, and improve blood sugar control for years. This study will see if the treatment works even better in children whose bodies may still have more ability to recover.
Type 1 diabetes happens when the immune system mistakenly attacks insulin-producing cells in the pancreas. Current treatment only replaces insulin from the outside—it doesn't fix the underlying immune problem. This trial is testing whether this medication could actually help the body repair itself and produce its own insulin again.
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You will receive two injections one month apart—either the BCG vaccine or a placebo (salt water injection). You won't know which one you're getting. After that, you'll be followed for 5 years with regular check-ups to measure your blood sugar control, insulin production, and overall health. You'll need to wear a continuous glucose monitor throughout the entire study so researchers can track how your body is responding.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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