Plain-English translation of NCT05185505 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing a combination of two medications— and —given alongside a procedure called chemoembolization, to help people with advanced liver cancer prepare for liver transplant surgery. The goal is to shrink tumors and make patients eligible for transplant who might otherwise be considered too sick. Researchers want to see if this treatment can work safely without harming the new liver after transplant.
Many people with liver cancer and cirrhosis are not eligible for life-saving transplants because their tumors are too large or advanced. This trial exists to test whether the new treatment can shrink these tumors enough to make transplant possible, while keeping people healthy enough to recover well after surgery.
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If you join this trial, you will receive a procedure called chemoembolization up to 4 times, spaced 3 months apart, along with regular infusions of the two-medication combination. You will have blood tests and imaging scans to monitor how your tumors respond. Throughout this time, you will work with the transplant team to prepare for your surgery, with the goal of eventually receiving your liver transplant once tumors shrink enough.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
United States