Plain-English translation of NCT05187429 on ClinicalTrials.gov โ ยท Source last updated ยท Translation generated ยท How we translate trials
Phase 1/2 โ A combined trial that checks safety and dosing while also starting to look at whether the treatment works.
This trial is testing a medication called Nivolumab to see if it can help people living with HIV who are already on antiretroviral therapy (HIV medications). The study has two parts: first, researchers will test different doses of the medication to find the safest amount, and then they will test whether the medication helps the body control HIV better, even if regular HIV medications are paused for a short time.
Even though modern HIV medications work very well to keep the virus undetectable, they don't cure HIV, and most people need to take them for life. This trial is exploring whether this medication could help boost the immune system to better control HIV on its own.
You likely qualify ifโฆ
You likely don't qualify ifโฆ
If you join, you would first go through a screening visit where your HIV levels and immune health are checked. Then you would receive a single infusion of either the medication or a placebo (salt water), which takes a few hours. In the second part of the study, some participants will have the option to pause their regular HIV medications for up to 6 months while researchers monitor how well their immune system controls the virus, before restarting treatment. You would have multiple follow-up visits over about 6 to 8 months total to have blood tests and check-ins.
AI-generated summary from trial data ยท Jun 3, 2026 ยท Not medical advice
Australia
Singapore