Plain-English translation of NCT05189314 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is testing two different ways to treat benign thyroid nodules—growths in the thyroid gland that are not cancer. You would receive either traditional thyroid surgery or a newer procedure called radiofrequency ablation (RFA), which uses heat to shrink the nodules. The study will compare how well each treatment works and how it affects your quality of life.
Thyroid nodules can cause uncomfortable symptoms like difficulty swallowing or breathing, and traditional surgery, while effective, carries some risks of nerve injury and other complications. This trial exists to see whether the newer heat-based treatment might be a safer or gentler alternative that still relieves symptoms without the surgical risks.
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You would be assigned to receive one of two treatments: either traditional thyroid surgery or the newer heat-based radiofrequency ablation procedure. After your treatment, you would have follow-up visits where doctors check how well it worked, whether your symptoms improved, and how your quality of life has changed. The study involves about 100 patients total and is currently recruiting.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
United States
Enrollment target
~100 participants
Started
August 2019
Primary completion
August 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in May 2026.
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Central contact
Jennifer H Kuo, MD MS
Columbia University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.