Plain-English translation of NCT05190094 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing Palbociclib combined with hormone therapy (letrozole or anastrozole) in women with advanced breast cancer that responds to hormones. Right now, doctors treat all patients with this combination, but only about half actually benefit from it. This trial also uses a new blood test technology to try to figure out upfront which patients will respond well to the treatment.
Currently, doctors give this medication combination to all eligible patients even though only about 50% respond well. This trial exists to find a way to predict ahead of time which patients will benefit, so doctors can avoid unnecessary treatment for those who won't respond and potentially find better options for them sooner.
You likely qualify if…
You likely don't qualify if…
You would take two daily pills at home—one medication for 3 weeks followed by 1 week off, repeating this cycle, and another hormone pill every day. You would have blood drawn regularly and imaging scans (CT or X-rays) every 3 months to check how well the treatment is working. The study continues until your cancer progresses, which on average takes about 2 years. You would visit the clinic periodically for check-ups and safety monitoring.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
Algeria
Jordan
Saudi Arabia