Plain-English translation of NCT05190978 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Breast Cancer research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether using a special surgical mesh called acellular dermal matrix (ADM) improves outcomes when women have their breasts reconstructed after mastectomy using implants. Right now, most surgeons use this mesh during reconstruction, but it has never been formally tested in a large, carefully controlled study to prove whether it actually helps or causes problems.
Nearly 100,000 women per year in the United States undergo breast reconstruction with implants, but doctors don't have solid scientific evidence showing whether surgical mesh truly improves safety and results. This study aims to generate that evidence so surgeons can make the best decisions for their patients.
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You would be randomly assigned to either receive surgical mesh during your initial breast reconstruction surgery or to have the same surgery without mesh. Both groups follow the standard two-stage breast reconstruction process, where a tissue expander is first placed to gradually stretch the skin, and then replaced with a permanent implant in a second surgery. Your surgical team will monitor your recovery and results over time to see how well each approach works.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States