High-flow oxygen at home to prevent breathing flare-ups in COPD

This trial is testing whether high-flow oxygen therapy used at home can help reduce severe flare-ups of COPD (a serious lung disease that makes breathing difficult). Participants who have recently been hospitalized for a severe breathing episode will either receive high-flow oxygen or standard oxygen therapy at home. The study will compare how many serious flare-ups or deaths occur in each group over time.

COPD patients who have had one severe breathing crisis are at high risk for another one, which often leads back to the hospital. This trial is designed to find out whether providing high-flow oxygen at home—instead of standard oxygen—might help prevent these dangerous flare-ups and keep people healthier.