Plain-English translation of NCT05201469 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Lupus Nephritis research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a new medication called to see if it can help treat lupus nephritis — a serious condition where lupus damages the kidneys. You would receive this medication (or a placebo) by IV infusion along with standard lupus treatments, and researchers will monitor how well it works and how safe it is over six months.
Lupus nephritis is a severe complication of lupus that can lead to kidney failure if not treated well. Current treatments don't work for everyone, so researchers are testing this medication to see if it offers a better option for people whose kidneys are being damaged by lupus.
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You would visit the clinic at weeks 0, 2, 4, 8, 12, 16, 20, and 24 to receive the study medication or placebo by IV infusion. You'll also take standard lupus medications (a steroid and mycophenolate) by mouth, with the steroid dose gradually reduced over 8 weeks. Throughout the six-month trial, the research team will check your kidney function, urine protein levels, and overall health through blood tests and urine collections.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
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