Recruiting

Testing a medication to reduce violence in schizophrenia

Plain-English translation of NCT05208190 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated June 2026 · How we translate trials

Read our Schizophrenia research guide →

Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.

What is this trial?

This study is testing whether , a medication used to treat schizophrenia, can help prevent violent behavior in adults who have experienced schizophrenia or schizoaffective disorder and have been violent in the past six months. Half of participants will take , while the other half will receive standard antipsychotic treatment. The trial will follow participants for 24 weeks to see which treatment better reduces the risk of future violent acts.

Violence can be a serious concern for some people with schizophrenia, and doctors need to know whether this medication is better than standard treatments at preventing it. This trial aims to fill that gap with solid research evidence.

Do you qualify?

You likely qualify if…

you have been diagnosed with schizophrenia or schizoaffective disorder
you have committed an act of violence within the past six months
you are between 18 and 65 years old
you are in overall stable health, in your doctor's judgment
you are able and willing to give informed consent to participate

You likely don't qualify if…

you have a serious medical condition or bone marrow disorder
you have had a severe allergic reaction or serious side effect to clozapine in the past
you are pregnant, breastfeeding, or unable to use reliable birth control
you have had recent thoughts of suicide or suicidal behavior, or your doctor believes you are at high risk for suicide
you have already tried clozapine at a full dose without benefit or with intolerance

What participation looks like

You will be randomly assigned to either take or receive standard antipsychotic treatment for 24 weeks. During this time, you will have regular visits for check-ins, blood tests to monitor your health and medication levels, and physical exams. Your doctor will track whether you have any violent incidents, and you'll complete assessments to measure your symptoms and any aggressive feelings or behaviors.

AI-generated summary from trial data · Jun 2, 2026 · Not medical advice

Trial locations(7 sites)

United States

University of California, Los Angeles, Los Angeles, California

Augusta University Research Institute, Inc., Augusta, Georgia

University of Maryland School of Medicine, Baltimore, Maryland

NYU Langone Medical Center, New York, New York

New York State Psychiatric Institute, New York, New York