Plain-English translation of NCT05210114 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Sickle Cell Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a non-invasive skin hydration sensor called the Delfin MoistureMeterEpiD to see if it can accurately measure how much water is in your body. The sensor may help doctors decide how much intravenous fluid you need during a sickle cell pain crisis, without giving you too much or too little fluid.
During sickle cell pain crises, doctors give intravenous fluids to help manage symptoms, but there are currently no reliable ways to measure whether patients are getting the right amount. Too much fluid can damage the lungs, while too little may not help the crisis. This trial aims to find a better tool to guide fluid treatment decisions.
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You will have skin hydration measured using the sensor during a clinic visit when you are feeling well, and again if you come to the hospital during a pain crisis—before and after you receive fluid treatment. The study will also collect blood and urine samples to compare with the sensor readings, helping doctors understand how well the sensor works.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
United States
Sponsor
Enrico Novelli
Enrollment target
~30 participants
Started
January 2022
Primary completion
December 2026
Age range
12 Years and older
Last updated on clinicaltrials.gov in November 2025.
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Central contact
Enrico Novelli, MD
University of Pittsburgh
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.